To use with Arduino 1.8 , you can download a official Proteus free trial and combine it with the free Arduino IDE. 1. Download and Install Software
This version was a major milestone for stability and ease of use: proteus 8.9 sp2 professional with arduino 1.8 free
How to Simulate Arduino in Proteus : 4 Steps - Instructables 12 Sept 2015 — Proteus 8
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The integration of Proteus 8.9 SP2 Professional Arduino 1.8 IDE Wokwi (Online): A free, browser-based Arduino simulator