"Great Grand Masti" brings together an ensemble cast, including Randeep Hooda, Manish Dayal, and Tusshar Kapoor, who reprise their roles from the previous installments. The movie follows the story of three friends, Amar (Randeep Hooda), Avinash (Manish Dayal), and Vivek (Tusshar Kapoor), who embark on a series of misadventures during a bachelor party. The film's script, penned by Aftab Shivdasani and Prem Soni, is replete with raunchy humor, double entendres, and pop culture references, making it a laugh-out-loud experience for the audience.